College Football Week 10 Preview

Our college football experts are back with their predictions for week 10 of the 2025-26 season.

College football is back and we're ready to share all our thoughts on the biggest games of Week 10. We saw major shake ups in the AP rankings after many of the top 25 teams battled it out with each other. Let's take a look at what week 10 has in store for us.

Penn State Nittany Lions 3-4 (NR) at Ohio State Buckeyes 7-0 (1)

This is not the marquee game that many thought it would be at the start of the season. Penn state hasn't won a game in the Big 10 this season and have fallen form #3 in the AP ranking to not being ranked after 4 straight losses. Interim coach Terry Smith has the almost impossible task of getting the Nittany Lions ready to take on an Ohio State team that is only allowing 5.9 points per game while scoring 36.4. Penn State is likely to fall to 0-5 now in the Big 10 and they'll play #2 ranked Indiana next week. There is a real chance that Penn State could go 1-8 in conference play this season.

As for Ohio State, they're 20.5 point favorites in this game and seem destined to play Indiana in the Big 10 championship game. They still have current #21 ranked Michigan to play this season but shouldn't have any real problem winning out and finishing the regular season 12-0.

The BetQL computer model has Ohio State winning in 97% of its simulations with a projected final score of 32.5-8. Our tip: Check out Ohio State -20.5 currently at -110 on ESPNBET.

Check out our full game analysis here.

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Georgia Bulldogs 6-1 (5) at Florida Gators 3-4 (NR)

SEC battle between Georgia and Florida might not be as exciting this season as it has been in the past, but even at 3-4, the Gators have shown their ability to shock the college football world this season. Georgia's lone loss of the season came to Alabama and at 4-1 in the SEC, only Alabama and Texas A&M have a better record. Florida is scoring 22.4 per game while allowing 20 points, they ranked 69th in passing and 102nd in rushing this season. The Bulldogs are scoring 33.7 and only allowing 19.6. Despite the differences in records this game should be a close one, with Georgia as a 7.5 point favorite.

The BetQL computer model has the Bulldogs winning in 70% of its projections with a final score of 25-18.5. DraftKings has the current total over/under at 50.5 which is 7 points more than what our computer model is currently projecting. Our tip: Take the under on DraftKings currently at -110.

Check out our full game analysis here.

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Arizona State Sun Devils 5-3 (NR) at Iowa State Cyclones 5-3 (NR)

A rematch of last year's Big 12 Championship features two teams that wont be making it to that game this season. Iowa State has dropped 3 in a row after starting off 5-0, while the Sun Devils have lost two of their last three. Iowa State is averaging more points per game and allow less than Arizona State, while also being ranked higher in passing and rushing. Neither of these teams can be happy with where they're currently at this season. Both teams were preseason favorites to top the Big 12 again this season, but BYU, Cincinnati, Texas Tech and Houston all have better records this season.

We've got Iowa State as a 6 point favorite according to our computer simulations with a final score of 26.5-20.5. Our tip: FanDuel has the spread at 7.5 points, take the Sun Devils +7.5 currently at -120.

Check out our full game analysis here.

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